<b>Cutaneous (Skin) & Subcutaneous (just under the Skin)
Medical Journal Article Annotated Citations

Latest Pubmed/Medline Search for Leiomyosarcoma with &&url

Latest Pubmed/Medline Search for Leiomyosarcoma with &&url    </b>


Gastroenterol Clin Biol 1999 Aug-Sep;23(8-9):991-2 
[Hepatic leiomyosarcoma revealed by cutaneous metastasis]. [Article in French] 
Pequignot R, Thevenot T, Permal S, Tulliez M, Legman P, Dhote R, Christoforov B. Publication Types:Letter 
<b>[Again---the first tumor you find may actually be a metastasis from a hidden primary LMS.  Ed.]</b>

&&url PMID: 10533154  


Dermatol Surg 1999 Jun;25(6):489-91
<b>Subcutaneous leiomyosarcoma on the face. </b>
Lin JY, Tsai RY. Department of Dermatology, Chang Gung Memorial Hospital, Taipei, Taiwan. 

.. Cutaneous leiomyosarcoma is a rare soft tissue sarcoma with a predilection for the lower extremities. Leiomyosarcoma of the face is very rare. Subcutaneous leiomyosarcoma has a higher likelihood of recurrence and metastases than that of the superficial dermal type. ,,, Leiomyosarcoma of the face is exceedingly rare. The deep subcutaneous type is thought to arise from the smooth muscle of the vascular wall. The neoplasm we report here has deep tumor invasion, high malignancy grade (3B), and large tumor size. Wide excision and postoperative radiotherapy were performed. ,,, <b>Subcutaneous leiomyosarcoma has a higher likelihood of recurrence and metastases than that of the superficial dermal type. The most effective treatment is wide excision with 3-5 cm lateral margins and a depth that includes subcutaneous tissue and fascia.</b>   

&&url PMID: 10469099 


Ann Dermatol Venereol 1999 Mar;126(3):235-42 Comment in: Ann Dermatol Venereol. 2000 Apr;127(4):411 Ann Dermatol Venereol. 2000 Apr;127(4):412-3 
<b>[Primary cutaneous leiomyosarcoma: 32 cases]. </b>[Article in French] 
Auroy S, Contesso G, Spatz A, Genin J, Margulis A, Lecesne A, Avril MF. Service de Dermatologie, Institut Gustave-Roussy, Villejuif. 

,,, Superficial leiomyosarcomas are rare tumors, which may be confined to the dermis or extend to subcutaneous tissues. ,,, We report the results of a retrospective study of 32 patients treated for leiomyosarcomas through a twenty-two year period (from 1975 to 1997). ,,, Mean age was 45 years, with 50% of patients less than 35 years of age. Forty seven percent of the tumors were located on the lower limbs and mean diameter was 2.8 cm. Three clinical types have been isolated: nodule beneath normal epidermis (50%), purple nodule ulcerated or not (28%), swelling tumor (22%). Sixteen percent were intradermal, whereas sixty nine percent involved subcutaneous tissues. With regard to tumor grade, 37% of tumors were grade I, 44% of tumors were grade II, and 19% were grade III. Immunohistochemical staining showed positive reactions for all tumors with anti-vimentin and anti-alpha smooth muscle actin. Main treatment was complete surgical excision. Follow-up informations were available for all patients and 75% of them had a follow up period longer than a year. <b>Five patients with leiomyosarcomas involving the subcutis developed local recurrences, and two of them died of the disease</b>. ,,, Leiomyosarcomas can occur at any age without predominant sex-ratio. Main prognostic factors are tumor size, distal location, depth of tumor invasion and pathological grade. Immunohistological staining with anti-alpha smooth muscle actin is more sensitive and specific than with anti-desmin or anti-HHF 35. Main treatment is surgical excision with wide margins. 

&&url PMID: 10394436 


Verh Dtsch Ges Pathol 1998;82:112-20 
<b>[Cutaneous and subcutaneous soft tissue tumors].</b> [Article in German]
Meister P. 
,,, Basically all types of soft tissue tumors can also be found in subcutaneous and cutaneous localisation. ,,,. Superficial leiomyosarcoma and atypical fibroxanthoma are examples of sarcomas, which in spite of histological criteria, which generally are associated with high grade malignancy, behave as low grade malignant tumors, i.e. chiefly with risk of recurrency albeit negligible risk of metastases. ,,,<b> In conclusion it is evident that exact tumor classification is the basic requirement for an optimal, prognosis-adapted therapy. </b>,,, 

&&url PMID: 10095423 


Am J Surg Pathol 1997 Sep;21(9):979-87 
<b>Cutaneous leiomyosarcoma. </b>
Kaddu S, Beham A, Cerroni L, Humer-Fuchs U, Salmhofer W, Kerl H, Soyer HP. Department of Dermatology, University of Graz, Austria. 

<b>We report the clinical, histopathologic, immunohistologic, and prognostic findings in 19 patients with cutaneous leiomyosarcoma, </b>eight males and 11 females (mean age, 66 years; age range, 41-93 years). The tumors presented mainly as solitary lesions and were located on the head and neck (eight lesions), trunk (four lesions), upper extremities (three lesions), and lower extremities (four lesions). Histopathologically, two predominant growth patterns were observed: nodular (12 cases) and diffuse (seven cases).  ,,,  Clinical follow-up revealed local recurrences in five patients (three cases with nodular pattern and two lesions with a diffuse pattern) after a period ranging from 8 months to 3 years after surgical excision. No distant metastases have been observed in our series. <b>We conclude that cutaneous leiomyosarcoma with a diffuse growth pattern may constitute a pitfall in histopathologic diagnosis because of the presence of only subtle criteria for malignancy.</b>  ,,,  Cutaneous leiomyosarcoma sometimes reveals local recurrences, but it has negligible potential for distant metastases. 

&&url PMID: 9298873 


Australas J Dermatol 1997 Feb;38(1):26-8 
<b>Primary leiomyosarcoma of the skin. </b>
Wargon O. Royal Prince Alfred Hospital, Sydney, New South Wales, Australia. 

<b>Leiomyosarcomas of the skin are frequently misdiagnosed clinically.</b> This tumour however, exhibits typical histological and immunohistochemical features. This collection of seven cases of cutaneous leiomyosarcoma on the trunk and limbs of adults with a mean age of 63 years and a range of 49-78 years demonstrates that the clinical diagnosis in each case, from seven different clinicians, did not include the correct diagnosis. In each case, the special immunohistochemical stains were helpful in making the diagnosis with actin and vimentin being positive and S100 and prekeratin stains being negative. Review of reported cases 
&&url PMID: 9046649 


Dermatol Surg 1996 Sep;22(9):761-8 
<b>Tumors with smooth muscle differentiation. </b>
Spencer JM, Amonette RA. Department of Dermatology and Cutaneous Surgery, University of Miami, FL 33101,USA. 

,,,:This review article describes the clinical presentation and course, histology, and treatment recommendations for benign and malignant smooth muscle tumors. ,,, Benign tumors exhibiting differentiation towards smooth muscle include smooth muscle hamartoma and leiomyoma. ,,, Immunohistochemical stains are also helpful in establishing a diagnosis. With solitary tumors, treatment for cosmesis or for painful leiomyomas is not a problem. Multiple leiomyomas, which may be painful or sensitive to cold or touch, are a therapeutic challenge, with reports of multiple medications being attempted in the literature. <b>Leiomyosarcoma are malignant tumors of smooth muscle.</b> They may be cutaneous and presumably arise from the arrector pilorum muscle, or subcutaneous, where they are believed to arise from vascular smooth muscle. <b>Cutaneous leiomyosarcomas frequently reoccur following excision, but rarely metastasize. Subcutaneous leiomyosarcomas frequently reoccur following excision and have a high metastatic rate.  Several recent reports have documented an increased frequency of visceral leiomyosarcomas in immunosuppressed patients. These tumors have been found to contain the Epstein Barr virus. </b>Treatment of leiomyosarcoma is wide excision.,,,. While leiomyomas are benign, their frequent sensitivity or pain necessitates treatment. Leiomyosarcomas are malignancies with a high reoccurrence rate, and when deep, a high metastatic rate. ...  

&&url PMID: 8874523 


Dermatol Surg 1996 Mar;22(3):268-73 
<b>Soft tissue sarcomas in dermatology. </b>
Fish FS. Department of Dermatology/Cutaneous Surgery, St. Paul RamseyMedicalCenter, MN55101,USA 

,,, and cutaneous leiomyosarcoma are uncommon soft tissue sarcomas that tend to have a high recurrence rate when removed with standard excisional surgery, and in some cases have been reported to metastasize. ,,, Wide excision and surgical techniques involving meticulous surgical margin control appear to be the most efficacious treatment for these problematic tumors. ,,, Cutaneous leiomyosarcoma is a rare superficial soft tissue sarcoma that has a high incidence of recurrence after excision and can metastasize. ,,, Currently, wide local excision is recommended with a 3-5 cm margin and removal of the underlying subcutaneous tissue. Mohs micrographic surgery has been used in a small number of cases with good success. ,,, When removing these tumors it is very important to take adequate margins. <b>Mohs micrographic surgery is proving to be very useful in treating these difficult neoplasms.</b> Review, tutorial 

&&url PMID: 8599739 


An Med Interna 1993 Feb;10(2):98 
<b>[Cutaneous metastases as a form of presentation of a retroperitoneal leiomyosarcoma]. </b>[Article in Spanish] 
Gironell Carrero A, Domingo Pedrol P, Costa Trachsel I. Publication Types: Letter 

&&url PMID: 8452982

<b>[Again---the first tumor you find may actually be a metastasis from a hidden primary LMS.  Ed.]</b>


Cancer 1992 Jul 15;70(2):490-2 
<b>Recurrent cutaneous leiomyosarcoma. </b>
Wascher RA, Lee MY. Department of Surgery, Tripler Army Medical Center, Honolulu, HI 96859.
 
,,, Soft tissue sarcomas comprise approximately 0.7% of all malignant neoplasms. Superficial leiomyosarcoma, a rare malignant lesion, constitutes 4.0-6.5% of all soft tissue sarcomas, an overall incidence of approximately 0.04% among all cancers. Currently, less than 125 cumulative cases of cutaneous and subcutaneous leiomyosarcoma have been reported in the English literature,,,, The authors report the case of a 70-year-old Japanese man with recurrent cutaneous leiomyosarcoma who was treated by wide local excision. A comprehensive literature survey is also presented. ,,, The patient is free from recurrence 1 year after wide local excision of a second recurrence of cutaneous leiomyosarcoma. Moreover, superficial leiomyosarcoma can be subdivided into cutaneous leiomyosarcoma and subcutaneous leiomyosarcoma, based on histopathologic and prognostic differences. ,,, <b>The treatment of choice of superficial leiomyosarcoma is wide local excision. Cutaneous leiomyosarcoma is associated with local recurrence only, although subcutaneous leiomyosarcoma undergoes metastatic spread in 30-60% of cases, with a 30-40% mortality rate</b>. 

&&url PMID: 1617597 


Cancer 1981 Jan 1;47(1):156-69 
<b>Leiomyosarcoma of the skin and subcutaneous tissue. </b>
Fields JP, Helwig EB. 

In a study of 65 primary cutaneous leiomyosarcomas and 15 primary superficial subcutaneous leiomyosarcomas, tumors occurred at any age but were more common in middle age and most common on the extremities. They developed as solitary painful or tender intracutaneous or subcutaneous nodules. Microscopically, the cutaneous leiomyosarcomas consist of a poorly delineated proliferation of spindle-shaped atypical myomatous cells arranged in interlacing fascicles which merge into collagenous stroma. Subcutaneous leiomyosarcomas are more sharply circumscribed and typically include a vascular pattern. <b>About 40% of the cutaneous leiomyosarcomas recurred, but none metastasized despite a high mitotic frequency and marked cytologic atypia. Among the 12 patients with subcutaneous leiomyosarcomas, one-half of the tumors recurred and one-third eventuated in metastasis or tumor-related death. Cutaneous leiomyosarcomas have a relatively benign biologic course and may be excised conservatively, but are less likely to recur if the local excision is wide enough to require a skin graft for closure of the surgical defect. For primary subcutaneous leiomyosarcoma, early wide local excision with adequate clear histologic borders constitutes rational treatment.</b>  
&&url PMID: 7459804  


Pathol Eur 1974;9(4):307-15 
<b>Cutaneous and subcutaneous leiomyosarcoma. A clinicopathologic study of 47 patients. </b>
Dahl I, Angervall L. 

A retrospective study of 47 patients with leiomyosarcoma of superficial (skin and subcutaneous) soft tissue is presented. ,,, Forty patients had a solitary tumour which, in 19 patients, was situated entirely or almost entirely in the corium. There were two distinct growth patterns for the leiomyosarcomas. The cutaneous tumours were poorly delimited and the subcutaneous tumours more well-circumscribed or nodular. Some three quarters of the tumours were located in the extremities, the thigh and hip regions being the predilection sites; the highest frequency was noted in patients in their seventies; the ages ranged between 25 and 89 years. The sex ratio (male to female) was 2 to 1. In 37 patients follow-up information was available, the follow-up period ranging from 1 month to 16 1/2 years; the median time was 6 years. One or more local recurrences developed in 15 patients. Seven out of the 47 patients had multiple leiomyosarcomas; 4 of these patients had already been operated on for a retroperitoneal leiomyosarcoma. Fourteen patients in the whole series died with metastases especially in the lungs. Metastases were seen particularly in patients with subcutaneous and multiple leiomyosarcomas. Our study suggest that the size and the mitotic activity of the tumour appear to have some prognostic value. <b>The initial surgical procedure was found to be the most important factor in influencing the outcome of the disease and it is stressed that leiomyosarcoma in superficial soft tissues should be treated by wide surgical excision. It is recommended that patients with multiple leiomyosarcomas in the superficial soft tissues should be subjected to further examination in order to exclude the possible occurrence of a retroperitoneal tumour.</b> ,,, 

&&url PMID: 4457785 
