

<b>Navelbine     Vinorelbine</b>



General Considerations

Online Patient Information

Clinical Trial Results


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<b>General Considerations</b>

Vinorelbine, or navelbine, is a vinca alkaloid drug that has been used to treat advanced sarcomas, in heavily pretreated patients.  

With LMS, navelbine seems to be used following upon a gemcitabine response that has progressed to resistance.  There have been two patients on the LMS List who have been placed on navelbine. 

Case 1 was a middle-aged male who had a partial response to Gemcitabine, but tumors grew after 3 months.  Navelbine was tried, but progression continued.

Case 2 is an older woman with low grade stage IV Uterine LMS.  She was unable to tolerate Gemcitabine because of gemcitabine-induced-hepatitis [two challenges].  She was placed on Navelbine, and had stable disease for 10 to 11 months.

Case 3 is an elderly lady with stage IV extremity LMS. She had a 10 or 11 month period of stable disease with Gemcitabine, then another 3 to 6 months of stable disease off chemotherapy.  She is now on Navelbine, but has not yet reached her first scans on it.

"Vinorelbine also induced responses in patients who had become resistant to regimens that included other vinca alkaloids. Overall, Vinorelbine was well tolerated. Toxicity, including         neurologic toxicity, was mild and reversible. Neutropenia was the most frequent dose-limiting toxicity." PMID: 10735904
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10735904&dopt=Abstract 

Myelosuppression of all elements of the blood occurs.  Grade 3 to 4 Neutropenia in 63%, Grade 3 anemia in 9%, and Grade 3 thrombocytopenia in 3%.  Nonhematological toxicity [constipation and neurologic toxicity have been mentioned] was generally mild [less than Grade 3] and reversible.
PMID: 12115359    PMID: 9157072
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12115359&dopt=Abstract 
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9157072&dopt=Abstract 



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<b>Online Patient Information</b>

Navelbine    Vinorelbine

http://www.nlm.nih.gov/medlineplus/druginfo/uspdi/203542.html 

http://www.cancerbackup.org.uk/info/vinorelbine.htm 

http://www.cancersource.com/Resources/drugguide/index.cfm?DiseaseID=1 

http://www.bchealth.com/services/cancer/drugs/nave.htm 

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<b>Clinical Trials Results and Medical Literature Search</b>

<b>The Clinical Trials results are the experiments done in the past to see if the drug works, and how well, and for how long. 


PubMed Searches
Directions for use:

When you click on the search string, it will connect you to Pubmed and display the first 20 citations [which they will call Summaries].  What you WANT is the complete listing of all the summaries of the article [which they will call Abstracts. ]  

Go to the second toolbar, and use the drop down menu to change summaries to Abstracts, and 20 to 200,  and sort by DATE, and then click on DISPLAY on that same toolbar.  You may have to wait while the page loads.

NOW you can save this search to a folder on your hard drive as "Navelbine Clinical Trials" as an HTML file - or as a text file.  The entire file, or just those parts which you wish to discuss, can be printed out and taken to talk over with your doctor.</b>



All articles on navelbine in Pubmed
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&db=PubMed&term=navelbine 

Clinical trials and sarcoma and navelbine
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&db=PubMed&term=clinical%20trial%20AND%20sarcoma%20AND%20navelbine     

Navelbine and sarcoma
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&db=PubMed&term=navelbine%20AND%20sarcoma   

Navelbine and Gemcitabine
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&db=PubMed&term=navelbine%20AND%20gemcitabine   

 


<b>ASCO Searches</b>
http://www.asco.org
You will have to go to the site and search the abstracts with keywords of the chemotherapy agent AND sarcoma.  It is an excellent site for results of clinical trials of new agents.
<b>http://www.asco.org/ac/1,1003,_12-002328,00.asp 
http://www.asco.org/prof/me/html/01abstracts/toc.htm</b>



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compiled by doctordee

March 2003


