<b>What are the response rates</b> (partial and complete) of this agent for <b>leiomyosarcoma</b>? What are the response rates <b>for my type of leiomyosarcoma</b> (e.g. uterine, gastro-intestinal, limb, retroperitoneal)? Because many researchers have tended to lump all soft tissue sarcomas together, <b>and even those that distinguish leiomyosarcoma from the soft tissue sarcoma group sometimes tend to lump all leiomyosarcomas together regardless of location</b>, getting a straight answer to these questions may be difficult.  [You should be seeing a sarcoma oncologist. Ed.]  

<b>What is the duration of the response</b>? In other words, how long before the tumors begin to re-grow?  With some regimens this may be less than six months.  The stock response of "we will have to see in your case" is not acceptable. You want the median response duration [50% of the people responding get more than this, 50% get less], and the range of durations.

<b>What is the impact upon survival</b>?  Particularly given the answer to question two, does response to this regimen increase survival time?  

<b>If surgery is feasible, how would you compare the duration of remission following surgery to that following chemotherapy treatment which produces a response</b>?  [Surgery is the preferred treatment for LMS.  Radiation and chemo resistant cancers do not usually get completely killed by radiation or chemo. Please see the Metastatic Disease page on this website for other options. Ed.]  [Sometimes tumors responding to chemotherapy are removed and then the chemotherapy continued. This combination might give longer disease free intervals. Ed.]  

<b>May I have a photocopy of any research you are relying upon to answer my questions</b>?  

<b>What side effect profile is associated with this chemotherapy regimen</b>?  

<b>How does the side effect profile interact with my other health conditions and their treatment</b>?  

<b>If I were your child, to whom would you send me for a second opinion</b>?