From: "Dr. D. Kossove" <doctordee@telkomsa.net>
To: "Bill Peeples" <WHPeeples@aol.com>
Subject: vegan diet and some supplements
Date: Saturday, September 20, 2003 10:01 PM


Date:    Sat, 20 Sep 2003 12:55:01 EDT
From:    Bill Peeples <WHPeeples@AOL.COM>
Subject: Re: new to list but learning

I thought you might find this of interest:

Med Hypotheses 2003 Jul;61(1):1-15     (ISSN: 0306-9877)
McCarty MF
Pantox Laboratories, San Diego, California, USA.
A great deal of effort is now being devoted to the development of new drugs
that hopefully will control the spread of inoperable cancer by safely
inhibiting tumor-evoked angiogenesis. However, there is growing evidence that certain
practical nutritional measures have the potential to slow tumor angiogenesis,
and it is reasonable to anticipate that, by combining several measures that
work in distinct but complementary ways to impede the angiogenic process, a
clinically useful 'multifocal angiostatic therapy' (MAT) might be devised. Several
measures which might reasonably be included in such a protocol are discussed
below, and include: a low-fat, low-glycemic index vegan diet, which may
down-regulate the systemic IGF-I activity that supports angiogenesis; supplemental
omega-3-rich fish oil, which has been shown to inhibit endothelial expression of
Flk-1, a functionally crucial receptor for VEGF, and also can suppress tumor
production of pro-angiogenic eicosanoids; high-dose selenium, which has
recently been shown to inhibit tumor production of VEGF; green tea polyphenols,
which can suppress endothelial responsiveness to both VEGF and fibroblast growth
factor; and high-dose glycine, whose recently reported angiostatic activity may
reflect inhibition of endothelial cell mitosis, possibly mediated by
activation of glycine-gated chloride channels. In light of evidence that tumor-evoked
angiogenesis has a high requirement for copper, copper depletion may have
exceptional potential as an angiostatic measure, and is most efficiently achieved
with the copper-chelating drug tetrathiomolybdate. If logistical difficulties
make it difficult to acquire this experimental drug, high-dose zinc
supplementation can achieve a slower depletion of the body's copper pool, and in any
case can be used as maintenance therapy to maintain an adequate level of copper
depletion. A provisional protocol is offered for a nutritionally based MAT
entailing a vegan diet and supplemental intakes of fish oil, selenium, green tea
polyphenols, glycine, and zinc. Inasmuch as cox-2 is overexpressed in many
cancers, and cAMP can boost tumor production of various angiogenic factors as well
as autogenous growth factors, adjunctive use of cox-2-specific NSAIDS may be
warranted in some cases.

 