From: "Dr. D. Kossove" <doctordee@telkomsa.net>
To: "LMS List" <L-M-SARCOMA@LISTSERV.ACOR.ORG>; "Rare Cancer List" <RARE-CANCER@LISTSERV.ACOR.ORG>; "LiF List" <LI-FRAUMENI@LISTSERV.ACOR.ORG>; "mesothelioma list" <MESOTHELIOMA@listserv.acor.org>; "ACC List" <adrenocorticalcarcinoma@yahoogroups.com>
Subject: Thromboembolism before and after cancer
Date: Sunday, February 16, 2003 8:13 AM

[These are edited because of the copyright...doreen]
Please remember that thromboembolism...clotting... is a risk factor for people who have chemotherapy, AND for people who have
surgery, as well as for people who have cancer.  Approximately 10% of cancer deaths are due to clotting.   Keep hydrated, and
watch out for long airplane trips or similar extended inactivity.

doreen
Together we are more, and more effective, than we are separately.

All correspondence is my personal opinion.  I am not an oncologist.  I am not practicing medicine online.  Provision of
information is for investigation and discussion with your doctors.

~~~~~~~~~~~~~~~~~~~~~~


http://www3.interscience.wiley.com/cgi-bin/abstract/102527881/START

American Journal of Hematology
Volume 72, Issue 2, 2003. Pages: 109-114
...

Thromboembolism preceding cancer: A correlation study
Hussain I. Saba 1 2 3 *, Farrah K. Khalil 1, Genevieve A. Morelli 1 3, Philip R. Foulis 1 3
1Sections of Hematology/Oncology, Departments of Internal Medicine, Pathology, and Laboratory Medicine, James A. Haley Veterans
Hospital, Tampa, Florida
2H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida
3University of South Florida College of Medicine, Tampa, Florida
,,,
Abstract
Thromboembolic (TE) events preceding cancer have been observed. Some studies failed to find this correlation.

,,, Medical records of 183 patients with established thromboembolic events documented in their records were selected and reviewed.

,,, Two hundred age- and sex-matched controls seen during the same period and without any evidence of TE were randomly selected
and charts reviewed for malignancy.

Cancer occurred after TE in 48 of 183 patients (26.2%). In controls, cancer was diagnosed in 23 (11.5%). This was statistically
significant ,,,

In the 64 primary TE patients, the cancer incidence was 37.5%. The 63 patients with recurrent TE had an incidence of 35.4%, and 56
secondary TE patients had an incidence of 27.1%.

Time between initial TE and cancer diagnosis was <6 months in 27 (56.3%) patients, between 6 months and 1 year in 12 (25.0%), 1-5
years in 5 (10.4%), and >5 years in 4 (8.3%). Fourteen (31.1%) TE patients presented with metastatic cancer. This study indicates
that thromboembolic events are important predictors of cancer. Cancer in this population occurs within a year in the majority of
patients. Cancer screening in patients without identifiable risk factors for thrombosis could be helpful for early detection,
diagnosis, and management of cancer. ,,,


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http://www.bloodjournal.org/cgi/content/abstract/101/4/1243

[ THIS abstract was HEAVILY edited because of copyright.  doreen]
       

Fibrin fragment D-dimer and the risk of future venous thrombosis 

Blood, 15 February 2003, Vol. 101, No. 4, pp. 1243-1248 
CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS
Mary Cushman, Aaron R. Folsom, Lu Wang, Nena Aleksic, Wayne D. Rosamond, Russell P. Tracy, and Susan R. Heckbert 
From the Laboratory for Clinical Biochemistry Research and Departments of Medicine, Pathology, and Biochemistry, University of Vermont, Colchester; Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis; Department of Internal Medicine, University of Texas, Houston; Department of Epidemiology, University of North Carolina, Chapel Hill; and Department of Epidemiology, University of Washington, Seattle. © 2003 by The American Society of Hematology.

Plasma D-dimer concentration rises more than 100-fold during acute deep vein thrombosis, but there are no prospective data concerning D-dimer as a risk factor for incident venous thrombosis in a general population.   ,,,,  D-dimer is strongly and positively related to the occurrence of future venous thrombosis.




 
 