<b>Medical Journal Article Annotated Citations</b>

Latest Pubmed/Medline Searches: 

&&url

&&url

&&url

Other site: replace the XXX with the site.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&db=PubMed&term=leiomyosarcoma%20XXX


Arch Surg 1980 Mar;115(3):244-8 
<b>Estrogen receptor proteins in diverse human tumors. </b>
Stedman KE, Moore GE, Morgan RT. 

One hundred three diverse benign and malignant human tissues have been assayed for estrogen receptor proteins. Receptors were detected in many endocrine and nonendocrine tumors. Tissues with estrogen receptor activity included four of five male breast carcinomas, 11 of 14 malignant melanomas, four of eight colon carcinomas, five of seven renal carcinomas, and various sarcomas and benign and normal tissues. Some tumors also had progesterone, androgen, and/or glucocorticoid receptors. These results suggest the use of hormones and hormone antagonists for therapy of a broad range of human cancer. Clinicians of diverse expertise should be aware of, and responsive to, potential endocrinological involvement in many dissimilar disease states. <b>[Uterine, breast, vulval, and ovarian tumors should be tested for estrogen receptors.  Sometimes estrogen blockers can be used for adjuvant or supplemental treatment.  Ed.]</b> 

&&url PMID: 7356378


Histopathology 1991 Jun;18(6):523-9 Erratum in: Histopathology 1991 Aug;19(2):198 
<b>Smooth muscle tumours of the external genitalia: clinicopathological analysis of a series. </b>
Newman PL, Fletcher CD. Department of Histopathology, St. Thomas's Hospital (UMDS) London, UK. 

Smooth muscle tumours of the external genitalia (vulva, scrotum and nipple) are uncommon and have received little attention in the literature. Given their purported close relationship to cutaneous (pilar) leiomyomatous lesions, we have studied 32 cases (18 vulva, 10 scrotum, four nipple) from 31 patients in order to compare clinicopathological features at the different sites. Only those in the nipple were comparable in size and histology to pilar leiomyomas. Vulval and scrotal tumours tended to be much larger and better circumscribed. Purely epithelioid lesions were only identified in the vulva (two cases) and at this site myxoid change and hyalinization were substantially more common. Almost all cases showed immunohistochemical evidence of muscle differentiation. On histological grounds, nine cases were classified as leiomyosarcoma (six scrotum, three vulva) but only one of the five with follow-up has led to the patient's death. <b>With the exception of nipple lesions, which are particularly uncommon, we would not support the traditional inclusion of genital smooth muscle tumours under the general heading of cutaneous leiomyoma/sarcoma, as vulval and scrotal lesions are clinicopathologically quite different.</b> 

&&url PMID: 1879812 



Histopathology 1991 Jun;18(6):523-9 Erratum in: Histopathology 1991 Aug;19(2):198 
<b>Smooth muscle tumours of the external genitalia: clinicopathological analysis of a series. </b>
Newman PL, Fletcher CD. Department of Histopathology, St. Thomas's Hospital (UMDS) London, UK. 

Smooth muscle tumours of the external genitalia (vulva, scrotum and nipple) are uncommon and have received little attention in the literature. Given their purported close relationship to cutaneous (pilar) leiomyomatous lesions, we have studied 32 cases (18 vulva, 10 scrotum, four nipple) from 31 patients in order to compare clinicopathological features at the different sites. Only those in the nipple were comparable in size and histology to pilar leiomyomas. Vulval and scrotal tumours tended to be much larger and better circumscribed. Purely epithelioid lesions were only identified in the vulva (two cases) and at this site myxoid change and hyalinization were substantially more common. ,,, On histological grounds, nine cases were classified as leiomyosarcoma (six scrotum, three vulva) but only one of the five with follow-up has led to the patient's death. <b>With the exception of nipple lesions, which are particularly uncommon, we would not support the traditional inclusion of genital smooth muscle tumours under the general heading of cutaneous leiomyoma/sarcoma, as vulval and scrotal lesions are clinicopathologically quite different</b>. 

&&url PMID: 1879812 


J Urol 1994 Jun;151(6):1643-5 
<b>Leiomyosarcoma of the penis. </b>
Pow-Sang MR, Orihuela E. Department of Surgery, University of Texas Medical Branch, Galveston 77550. 

<b>The third case of leiomyosarcoma of the foreskin is reported. A review of the literature indicates that this lesion, which is similar to cutaneous leiomyosarcoma that is seen elsewhere in the body, has a low grade of malignancy. This finding is in contrast to leiomyosarcoma of the penis, which arises in deep structures and tends to metastasize. Circumcision appears to be the most effective treatment for leiomyosarcoma of the foreskin.</b> 

&&url PMID: 8189587 


J Surg Oncol 1986 Mar;31(3):191-8 
<b>Neoplasms in skin and subcutis over the breast, simulating breast neoplasms: case reports and literature review.</b>
Ilie B. 
Twenty cases of neoplasms in skin and subcutaneous tissue over the breast were reviewed. There were 17 women, from 15 to 70 years of age, and three men, from 25 to 66 years of age. Among the benign skin neoplasms, superficial leiomyoma, granular cell tumor, and eccrine acrospiroma were misdiagnosed clinically as primary breast carcinoma. Among the malignant neoplasms in subcutaneous tissue, there were three metastatic malignant melanomas, one metastatic epidermoid bronchogenic carcinoma, and two malignant lymphomas. It is interesting that four of these six patients had no prior history of malignant lesion, the subcutaneous nodule presenting as the first manifestation of an occult primary. It is concluded that histological diagnosis of such tumors may lead to avoidance of unnecessary radical surgery. 
&&url PMID: 3014220
