<b>Medical Journal Article Annotated Citations

Latest Pubmed/Medline Search for Leiomyosarcoma &&url </b>

Orv Hetil 1997 Jan 26;138(4):195-8 
<b>[Experience in the treatment of breast sarcomas].[Article in Hungarian] </b>
Farkas E, Orosz Z, Kovacs T, Koves I. Orszagos Onkologiai Intezet Budapest.

Authors operated on 6339 malignant breast tumors at the Department of Surgery, National Institute on Oncology between 1980 and 1994. The records of 14 patients with sarcomas of the breast were analyzed. These included 2 malignant phyllodes tumors, 3 malignant fibrous histiocytomas, 2-2 fibrosarcomas and carcinosarcomas and liposarcoma, angiosarcoma, leiomyosarcoma, osteosarcoma and dermatofibrosarcoma protuberans one of each. During this period 5 patients died, 9 are living without evidence of tumor. Analysing these 14 cases authors present their policy in surgical therapy of breast sarcomas compared with literature data. <b>They emphasise the importance of wide resection margins for prevention of tumor progression. The above-mentioned principle is valid for local recurrences so radicalization of the previous conservative breast surgery may be necessary in selected cases. Intraoperative histological examination is recommended to verify that the resection margins are tumor free. Axillary block dissection is not necessary except in cases when palpable, firm lymph nodes are present in the region. </b>Depending on the histological grade adjuvant radiotherapy could be considered but its effectiveness is not proven. 
&&url PMID: 9072752 


Aust N Z J Surg 1997 Jan;67(1):71-2 
<b>Breast metastases from primary leiomyosarcoma.</b> 
Tulasi NR, Kurian S, Mathew G, Viswanathan FR, Roul RK. Department of Oncology, GKNM Hospital, Coimbatore, India. 
Two cases of metastatic leiomyosarcoma of the breast are presented. The reasons why they are considered as secondary tumours and not primary tumours are also discussed. 
&&url PMID: 9033385 


Neoplasma 1992;39(6):375-9 
<b>Sarcomas of the breast: a multicenter series of 70 cases. </b>
Ciatto S, Bonardi R, Cataliotti L, Cardona G. Center for Study and Prevention of Oncological Diseases, Firenze, Italy. 
A multicenter retrospective series of 70 breast sarcomas (,,, leiomyosarcoma (1)) was reviewed. The average follow-up was 5.9 years. Diagnostic tests (palpation, mammography, sonography and cytology) were poorly sensitive, and a large proportion of cases, appearing as regular, sharp bordered, rounded masses were diagnosed as benign fibroadenomas. Surgery (limited (29), mastectomy (41)) was the treatment of choice. Axillary nodes were rarely involved (2 of 31) at pathologic staging. No significant predictors of local recurrences (12 cases) were observed although recurrences were more frequent in larger lesions (0-20 mm = 1.1%, 21-50 mm = 1.7%, > 50 mm = 6.1% women-year) and in cases treated with limited surgery (limited surgery 4.6%, mastectomy 2.0% women-year). Distant metastases (16 cases) were less frequent in malignant cystosarcoma phyllodes or liposarcoma patients, but no other significant predictors of distant metastases were evidenced. Five-year disease-free or overall survival was 50% or 66%, respectively. <b>The study confirms that breast sarcomas are rare, difficult to diagnose, but can be cured by surgical treatment in a considerable proportion of cases.</b> Multicenter study 
&&url PMID: 1491728 


Am J Clin Pathol 1989 Oct;92(4):500-5
<b>Primary recurrent leiomyosarcoma of the breast. Case report with ultrastructural and immunohistochemical study and review of the literature. </b>
Arista-Nasr J, Gonzalez-Gomez I, Angeles-Angeles A, Illanes-Baz E, Brandt-Brandt H, Larriva-Sahd J.   
Department of Pathology, Instituto Nacional de la Nutricion, Mexico, D.F. 

.. <b>As a group, they have better prognosis than other sarcomas of the breast, although the possibilities of recurrence or dissemination exist, even many years after the primary extirpation.</b> The size of the tumor and mitotic activity seem to be of little prognostic value. Mammary leiomyosarcoma shares clinical and pathologic similarities with subcutaneous leiomyosarcoma in other anatomic sites. Review of reported cases 
&&url PMID: 2679042



Cancer 1981 Apr 1;47(7):1883-6 
<b>Leiomyosarcoma of the breast: a case of long survival and late hepatic metastasis. </b>
Chen KT, Kuo TT, Hoffmann KD. 

<b>A case of leiomyosarcoma of the breast that metastasized to the liver 15 years after mastectomy is reported. Leiomyosarcoma appears to have less aggressive biologic behavior than other types of breast sarcomas.</b> Analysis of the reported cases of smooth muscle tumors of the breast revealed some guidelines for the histologic diagnosis of these tumors. Tumors with three or more mitoses per 10 HPF are leiomyosarcomas, and those with no mitotic activity, necrosis, and significant cellular atypia are leiomyomas. The borderline cases are best considered smooth muscle tumors with uncertain malignant potential. <b>[A mitotic rate of one per 10 HPF might be just a very low grade LMS.  Best to have slides reviewed by a sarcoma oncologist at a sarcoma center. Ed. ] </b>
&&url PMID: 7194732


Arch Surg 1980 Mar;115(3):244-8 
<b>Estrogen receptor proteins in diverse human tumors. </b>
Stedman KE, Moore GE, Morgan RT. 

One hundred three diverse benign and malignant human tissues have been assayed for estrogen receptor proteins. Receptors were detected in many endocrine and nonendocrine tumors. Tissues with estrogen receptor activity included four of five male breast carcinomas, 11 of 14 malignant melanomas, four of eight colon carcinomas, five of seven renal carcinomas, and various sarcomas and benign and normal tissues. Some tumors also had progesterone, androgen, and/or glucocorticoid receptors. These results suggest the use of hormones and hormone antagonists for therapy of a broad range of human cancer. Clinicians of diverse expertise should be aware of, and responsive to, potential endocrinological involvement in many dissimilar disease states. <b>[Uterine, breast, vulval, and ovarian tumors should be tested for estrogen receptors.  Sometimes estrogen blockers can be used for adjuvant or supplemental treatment.  Ed.]</b> 
&&url PMID: 7356378

