<b>Medical Journal Article Annotated Citations

Latest Pubmed/Medline Search for Leiomyosarcoma with &&url   </b>

Acta Otorhinolaryngol Belg 1999;53(3):199-205 
<b>Possibilities and limitations of endoscopic management of nasal and paranasal sinus malignancies. </b>
Stammberger H, Anderhuber W, Walch C, Papaefthymiou G. Department of ENT, University Medical School of Graz, Austria.

,,, From 1989-1999 <b> we have treated 43 patients with invasive/destructive tumors of the paranasal sinuses and the anterior skull base strictly endoscopically, transnasally.</b> ,,, Whereas the very first patients were approached endoscopically in a palliative intention, we have started endoscopic surgery for selected malignancies with curative intention in the last years. ,,, Our first results appear to indicate, that outcome is at least equal to standard external approaches, however with excellent functional terms and significantly better overall quality of life. The limitations result from the anatomical spread of the tumor, when extensive infiltration of orbit, dura/brain and other vital structures exist. However, in experienced hands, endoscopic surgery in this region can be rather radical, bone and even dura of the anterior skull base can be resected as can the periorbit, and all structures reconstructed in the same session. Endoscopic techniques lend themselves very well to cooperation with neighbouring specialities like neurosurgery. In individual cases, gamma-knife therapy has proven an extremely helpful adjunctive. ,,, However we recommend, that these techniques are only applied at centers, where all other surgical approaches can be performed, should need for this arise.  

&&url PMID: 10635393


ORL J Otorhinolaryngol Relat Spec 1996 Mar-Apr;58(2):115-20
<b>Leiomyosarcoma of the nasal cavity. Case report and literature review. </b>
Lippert BM, Godbersen GS, Luttges J, Werner JA. Department of Otorhinolaryngology, Head and Neck Surgery, University of Kiel, Germany. 
Leiomyosarcoma (LMS) accounts for approximately 7% of all soft tissue sarcomas and occurs most frequently in the gastrointestinal tract and uterus. LMS of the nasal cavity and paranasal sinuses are rare and only about 40 cases of LMS of the nose and paranasal sinuses have been reported in the literature. A further case of LMS of the right turbinate is presented, treated twice by surgery. To date, the patient has been free of disease for more than 48 months. The symptoms, pathology, treatment and prognosis, and origin of this tumor are discussed.  <b> Initially, LMS should be treated by extensive surgical excision, but long-term follow-up is essential due to the high rate of local recurrence. Radiotherapy and chemotherapy are insufficient therapeutic approaches. Frequency of recurrence and prognosis depend on the tumor site. The prognosis of LMS of the nasal cavity is better than LMS of the paranasal sinuses.</b> Review, tutorial 

&&url PMID: 8736058


HNO 1995 Apr;43(4):250-2 
<b>[Rare tumor of the nose and paranasal sinuses. Leiomyosarcoma]</b>. [Article in German] 
Schmal F, Laubert A. Universitats-HNO-Klinik Munster. 

Leiomyosarcoma is a rare malignant tumor of the nose and paranasal sinuses. Including our patient, 32 cases have been reported in the literature.<b> Radical surgery is currently the best therapy. In comparison with results of conventional irradiation, postoperative neutron treatment appears to be more effective.</b> Review of reported cases 

&&url PMID: 7790237
